A Case of Pregabalin-Induced Parkinsonism
Neurology India, cilt.68, sa.6, ss.1469-1471, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 6
- Basım Tarihi: 2020
- Doi Numarası: 10.4103/0028-3886.304071
- Dergi Adı: Neurology India
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1469-1471
- Anahtar Kelimeler: Drug-induced parkinsonism, movement disorders, parkinsonism, pregabalin, secondary parkinsonismKey Messages, The mechanism of parkinsonism caused by pregabalin has reported very rarely, and the mechanism has not yet defined entirely to this day, Further studies should be performed
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Drug-induced parkinsonism is the second common movement disorder after Parkinson's disease. It occurs due to the use of not only neuroleptics but also some other medications as pregabalin. Pregabalin is an antiepileptic drug and a structural analog of gamma-aminobutyric acid (GABA), and its use decreases the release of several neurotransmitters. In this case report, we present a 53-year-old female patient with the signs of parkinsonism following pregabalin treatment. Drug-induced parkinsonism was diagnosed based on the clinical features, investigations, and resolution of the complaints. The symptoms relieved after the treatment stopped at a follow-up of 10 days. Due to the rare report of pregabalin-induced parkinsonism, we aim to enhance clinicians' awareness of pregabalin's probable side effects.