Oxidative stress, varicocele, and disorders of male reproduction
Fundamental Principles of Oxidative Stress in Metabolism and Reproduction: Prevention and Management, Elsevier, ss.215-232, 2024
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2024
- Doi Numarası: 10.1016/b978-0-443-18807-7.00014-4
- Yayınevi: Elsevier
- Sayfa Sayıları: ss.215-232
- Anahtar Kelimeler: Antioxidant therapy, Male infertility, Oxidative stress, Reactive oxygen species, Varicocele
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Oxygen byproducts induce reactive oxygen species during mitochondrial processes, leading to oxidative stress affecting cellular structures and DNA. Varicocele, a common condition, contributes significantly to male infertility through increased scrotal heat, hormonal imbalances, and testicular hypoxia, intensifying oxidative stress. The consequences include sperm parameter abnormalities and proteomic alterations in seminal plasma proteins. Diagnostic methods like chemiluminescence assess oxidative stress, with sperm DNA fragmentation being a crucial indicator. Management involves surgical interventions, antioxidants, and lifestyle changes, although antioxidant efficacy is debated. This chapter also explores genetic and epigenetic factors in varicocele-induced infertility. Despite promising avenues, antioxidant use requires cautious consideration due to endogenous defense complexities.