Filamentous fungi, and their antifungal susceptibilities, isolated from patients at an oncology hospital in Turkey Hongos filamentosos aislados de pacientes en un hospital oncológico en Turquía y sus sensibilidades antifúngicas
Revista Iberoamericana de Micologia, cilt.43, sa.2, ss.36-39, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.riam.2026.01.003
- Dergi Adı: Revista Iberoamericana de Micologia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, DIALNET
- Sayfa Sayıları: ss.36-39
- Anahtar Kelimeler: Mold, Aspergillus, Antifungal susceptibilities, Oncology patients, Filamentous fungi
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background Fungal infections affect especially to patients with cancer and those who are immunocompromised. Aims We analyzed the prevalence of filamentous fungi in patients at Ankara Oncology Education and Research Hospital from 2022 to 2024; antifungal susceptibility tests were also carried out. Methods Filamentous fungi were analyzed by MALDI-TOF (matrix-assisted laser desorption ionization-time of flight), and antifungal susceptibility was tested by the broth microdilution method. Results Filamentous fungi were recovered from 66 (6.5%) of 1020 samples: 31(47%) deep tracheal aspirates, 13 (19.7%) sputum, 10 (15.2%) ear swabs, nine (13.6%) biopsies, and three (4.5%) bronchoalveolar lavage samples. Filamentous fungi other than Aspergillus grew from 10 (15.2%) samples, while Aspergillus species were recovered in 56 (84.8%). Of the 56 Aspergillus , 21 (31.8%) were Aspergillus fumigatus , 15 (22.7%) were Aspergillus flavus , 14 (21.2%) were Aspergillus niger , three (4.5%) were Aspergillus terreus , and one strain (1.5%) each of the following species were identified: Aspergillus tamarii , Aspergillus nidulans , and Aspergillus calidoustus. Of 66 patients from whom a fungal isolate was recovered, 50 (75.8%) had cancer. Minimum inhibitory concentrations (MICs) were determined in 45 (80.4%) Aspergillus isolates. Eight (8/19) A. fumigatus, seven (7/13) A. flavus , and three (3/11) A. niger were non-wild type (WT) according to amphotericin B MIC values. Four (4/13) A. flavus and two (2/19) A. fumigatus were non-WT according to itraconazole MIC values. One (1/13) A. flavus was non-WT according to voriconazole MIC value. Conclusions The filamentous fungi recovered from the patients showed high antifungal MIC/MEC values, and some isolates had high amphotericin B MICs. Voriconazole was effective in vitro against A. fumigatus .