Comparison of Sedation Efficacy Between Propofol-ketamine and Propofol-fentanyl Combinations in Short Gynecological Procedures

Tamdogan I., Degermenci M., Olgun Keles B., Tutar M. S.

Journal of Perianesthesia Nursing, cilt.41, sa.2, ss.410-415, 2026 (SCI-Expanded, SSCI, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 2
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.jopan.2025.07.019
  • Dergi Adı: Journal of Perianesthesia Nursing
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.410-415
  • Anahtar Kelimeler: deep sedation, hemodynamic monitoring, fentanyl, gynecologic anesthesia, ketamine, propofol
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Purpose This study aimed to compare the sedoanalgesic efficacy and side effects between propofol-ketamine and propofol-fentanyl combinations in short gynecological procedures for increasing surgical analgesia and improving patient comfort. Design This was a randomized (1:1), double-blind, prospective trial. Methods This randomized, double-blind controlled trial included patients who underwent short gynecological procedures lasting less than 30 minutes. Group K (n = 30) received 0.5 mg/kg ketamine and 1 mg/kg propofol, whereas group F (n = 30) received 1 mcg/kg fentanyl and 1 mg/kg propofol. The sedation levels, hemodynamic changes, adverse events, and both surgical and patient satisfaction were evaluated. Findings Lower extremity movement was more frequently observed in group F ( P = .020), but surgical satisfaction was higher in group K ( P < .001). Both groups exhibited similar sedation, surgical time, and patient satisfaction scores. However, group F had shorter recovery times and exhibited more frequent apnea and desaturation. Furthermore, postoperative dizziness was more common in this group ( P = .003). Conclusions Both drug combinations provide safe anesthesia with stable hemodynamics and fewer side effects. The use of propofol-ketamine resulted in fewer lower extremity movements, leading to greater surgical satisfaction.