Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion
Polish Journal of Pathology, cilt.74, sa.4, ss.282-285, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 74 Sayı: 4
- Basım Tarihi: 2023
- Doi Numarası: 10.5114/pjp.2023.134321
- Dergi Adı: Polish Journal of Pathology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Directory of Open Access Journals
- Sayfa Sayıları: ss.282-285
- Anahtar Kelimeler: biphenotypic sinonasal sarcoma, PAX3/FOXO1, low-grade neoplasia
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Biphenotypic sinonasal sarcoma (BSNS), previously known as low-grade sinonasal sarcoma, is a rare tumour of the sinonasal tract, first described in 2012. It involves both myogenic and neural differentiation and is characterized by PAX3 rearrange-ment. MAML3 is the most frequent fusion partner of PAX3; however, its partner remains unidentified in a subset of cases. These tumours have significant local recur-rence rates but lack metastatic potential. Here, we report a case of BSNS with PAX3/ FOXO1 fusion and discuss its clinicopathological features and differential diagnosis.