Benign Breast Disorders in Levonorgestrel-releasing Intrauterine Device Users: Evidence from a Prospective Cohort Study Levonorgestrel Salınımlı Rahim İçi Araç Kullanımında Benign Meme Bozuklukları: Prospektif Kohort Çalışması
Anatolian Journal of General Medical Research, cilt.36, sa.1, ss.61-68, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/anatoljmed.2026.17894
- Dergi Adı: Anatolian Journal of General Medical Research
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.61-68
- Anahtar Kelimeler: benign breast disorders, breast cysts, fibrocystic breast disease, Levonorgestrel-releasing intrauterine device (LNG-IUD), Mirena®
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: This study aimed to evaluate the incidence of benign breast disorders in women using levonorgestrel-releasing intrauterine devices (LNG-IUD) and to assess the relationship between duration of use and these outcomes. Methods: A prospective observational cohort study was conducted at a tertiary care center. The study included premenopausal women aged 18 years or older who had used an LNG-IUD for at least 12 months. Breast imaging was performed using standard ultrasonography. Lesions were classified according to the breast imaging reporting and data system. The primary outcome was the presence of benign breast diseases, including simple cysts, fibroadenomas, and fibrocystic changes. Results: Eighty women with a mean age of 47.2±4.4 years and a mean body mass index (BMI) of 28.1±3.9 kg/m2 were included in the study. Benign breast abnormalities were found in 57 women (71.2%); among these, the majority (61.3%) were simple cysts, followed by fibrocystic changes (15.0%) and fibroadenomas (1.3%). Women with benign outcomes had lower baseline hemoglobin levels than those without benign outcomes (12.4 vs. 13.1 g/ dL, p=0.018). No significant differences were observed in age, BMI, or number of births. In multivariate logistic regression, LNG-IUD duration was not significantly associated with benign outcomes (adjusted odds ratio=0.44, 95% confidence interval: 0.12-1.57). Conclusion: Benign breast complications are common among women using LNG-IUDs and are not affected by duration of device use. These findings support the safety profile of LNG-IUDs with respect to benign breast health and may help clinicians provide reassurance during contraceptive counseling.