Potential role of ocular surface microbiota in keratoconus etiopathogenesis
Expert Review of Ophthalmology, cilt.16, sa.5, ss.333-341, 2021 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 5
- Basım Tarihi: 2021
- Doi Numarası: 10.1080/17469899.2021.1942844
- Dergi Adı: Expert Review of Ophthalmology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Chemical Abstracts Core, CINAHL, EMBASE
- Sayfa Sayıları: ss.333-341
- Anahtar Kelimeler: Corneal ectasia, keratoconus, ocular inflammation, ocular microbiota, ocular immunology
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Keratoconus is the most common corneal ectatic disease and the most common cause of corneal transplantation in developed countries. The etiopathogenesis of the disease remains unclear. Areas covered: The human body hosts a remarkably abundant and diverse community of microbial species called microbiota. Advances in next-generation sequencing (NGS) technology and bioinformatics have facilitated the characterization of human microbiota. Previous studies have shown that there is an alteration of ocular microbiota in inflammatory and autoimmune ocular diseases. The purpose of this review article is to evaluate the potential effect of ocular microbiota on the pathophysiology of keratoconus. Expert opinion: Recent studies have shown the low-level chronic inflammatory process in keratoconus. A regulatory interaction has been demonstrated between human microbiota and Toll-like receptors, which are innate immune system receptors. In addition, Toll-like receptor activity in keratoconus has been shown to be higher than in normal individuals. Therefore, the alteration of ocular microbiota may have a potential role in keratoconus etiopathogenesis. Further research is required on this subject.