Associations of Upper-Extremity Exercise Capacity and Grip Strength With Cognitive Domains in Patients With COPD
Respiratory Care, cilt.69, sa.5, ss.595-602, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69 Sayı: 5
- Basım Tarihi: 2024
- Doi Numarası: 10.4187/respcare.11610
- Dergi Adı: Respiratory Care
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.595-602
- Anahtar Kelimeler: COPD, cognitive function, exercise capacity, muscle strength, upper extremity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND: Cognitive impairment (CI), which has been reported in COPD, has been related to physical performance. However, the association between CI and upper-extremity functions is unknown. We aimed to compare upper-extremity exercise capacity and grip strength between subjects with COPD with and without CI and to determine the relationship of upper-extremity functions with specific cognitive domains. METHODS: In this cross-sectional study, 76 subjects with COPD (mean age 66.8 ± 7.5 y, FEV1% 47.12 ± 14.10) were classified as with and without CI according to the Montreal Cognitive Assessment. Clinical characteristics, upper-extremity exercise capacity (6-min pegboard ring test [6PBRT]), grip strength (hand dynamometer), dyspnea severity (modified Medical Research Council dyspnea scale), disease-specific health status (COPD Assessment Test), and disease-specific quality of life (St George Respiratory Questionnaire) were compared between groups, and the relationship of upper-extremity functions with cognitive subdomains was analyzed by multivariate regression analysis. RESULTS: The number of 6PBRT rings (P = .01) and the grip strength (P = .033) were lower in subjects with CI. Subjects with CI had lower FEV1% (P=.038), arterial oxygenation (P=.002), exercise habits (P=.033), health status (P = .01), quality of life (P = .042); and higher dyspnea (P<.001), smoking consumption (P=.032), emergency admission (P = .02), and hospitalization (P = .042). The adjusted model showed that executive functions and attention were related to upper-extremity capacity (f = 14.4 and ẞ = 10.2, respectively) and hand-grip strength (f = 1.85 and ẞ = 1.49, respectively). CONCLUSIONS: These findings suggest that upper-extremity functions might be decreased especially concerning executive functions and attention in subjects with COPD with CI.