Acute tissue response of biliary and gastrointestinal system to methyl-tertiary-butyl ether infusion into the gallbladder of rabbits
Turkish Journal of Gastroenterology, cilt.8, sa.1, ss.41-44, 1997 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 1
- Basım Tarihi: 1997
- Dergi Adı: Turkish Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.41-44
- Anahtar Kelimeler: Gallstone, Methyl-butyl-ether
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
New approaches have been recently introduced in treatment of gallstones. Gallstone dissolution with methyl tertiary butyl ether, one of these new techniques has been used by some authors. Eight New Zealand type rabbits were studied. 5 French Biliary drainage catheters was surgically sutured into the gallbladder of rabbits. Immediately after laparotomy, methyl tertiary butyl ether was manually instilled into the gallbladder in acquits of 0.5-0.7 ml for 6 hours period. Saline solution was instilled into the gallbladder of control animal through the catheter. Animals were sacrificed after 6 hours. On light microscopy, rabbits treated with methyl tertiary butyl ether had different degrees of gallbladder and common bile duct necrosis, proprial hemorrhage and edema. Control animals receiving saline solution showed small hemorrhages and necrosis in the gallbladder. The severity of necrosis was extremely high in the methyl tertiary butyl ether treated rabbits as compared with the controls. Methyl tertiary butyl ether application produced severe acute side effects in our rabbit study. Although the results of this animal study can not be directly transferred to humans, the data suggest that methyl tertiary butyl ether should be used in gallstone therapy with caution and a meticulous follow-up is necessary in the treated patients.