Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation
Turkish Journal of Gastroenterology, cilt.21, sa.4, ss.433-438, 2010 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 4
- Basım Tarihi: 2010
- Doi Numarası: 10.4318/tjg.2010.0132
- Dergi Adı: Turkish Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.433-438
- Anahtar Kelimeler: Acinar cell degeneration, apoptosis, hemorrhage, melatonin treatment, obstructive acute pancreatitis, edema
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background/aims: The aim of this study was to address the protective effects of exogenous melatonin injections intraperitoneally on the histopathological changes in a model of obstructive acute pancreatitis. Methods: In this study, ductal ligation technique was used in 20 adult male Wistar Albino rats to develop a model of obstructive acute pancreatitis and beginning pancreatic atrophy. Melatonin 20 mg/kg solution was injected in one group of rats intraperitoneally for one week and results were compared with the control group regarding histopathological findings in the pancreatic tissue. Results: The apoptosis rate in control group rats was 30.5%, while it was 12.7% in the melatonin group. Pancreatic edema, hemorrhage and polymorphonuclear leukocyte infiltration decreased remarkably in the melatonin group compared to the control group. Conclusions: Injection of exogenous melatonin in rats with obstructive acute pancreatitis for seven days prevents acinar cell degeneration, apoptosis and polymorphonuclear leukocyte infiltration.