Quantitative assessment of volume-based metabolic parameters in early-stage invasive ductal breast cancer: Impact of different standardized uptake value thresholds on prognostic factors - A comprehensive analysis
Hellenic Journal of Nuclear Medicine, cilt.27, sa.3, ss.229-235, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 3
- Basım Tarihi: 2024
- Dergi Adı: Hellenic Journal of Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.229-235
- Anahtar Kelimeler: Breast cancer, Metabolic tumor volume, Total lesion glycolysis, Volume, based metabolic parameters
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: This study compares volume-based metabolic parameters in early-stage invasive ductal breast cancer using different standardized uptake value (SUV) thresholds and examines their association with immunohistochemical factors. Subjects and Methods: A retrospective analysis included 135 patients with early-stage invasive ductal breast cancer who underwent preoperative fluorine-18-fluorodeoxyglucose 18 positron emission tomography/computed tomography ( F-FDG PET/CT) scans. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were derived using absolute SUV threshold methods and fixed % maximum tumor SUV threshold methods. Associations with immunohistochemical factors were explored, and receiver operating characteristic curves were generated. Results: Metabolic tumor volume 2.5 and TLG 2.5 showed stronger correlations with maximum tumor SUV values. Metabolic tumor volume 2.0 and TLG 2.0 had superior area under the curve (AUC) values in predicting estrogen and progesterone receptor negativity. Metabolic tumor volume 2.0 and TLG 2.0 were superior in distinguishing low and high-grade tumors. Conclusion: Absolute SUV threshold methods with a threshold of 2.0 are recommended for calculating volume-based metabolic parameters due to their strong correlation with immunohistochemical factors in invasive ductal breast cancer.