Efficacy of granulocyte-macrophage colony-stimulating factor on the survival of ischaemic skin flaps in rats
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, cilt.39, sa.4, ss.193-196, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 4
- Basım Tarihi: 2005
- Doi Numarası: 10.1080/02844310510006132
- Dergi Adı: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.193-196
- Anahtar Kelimeler: ischaemic flap, GM-CSF, flap survival
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Our objective was to find out whether granulocyte-macrophage colony-stimulating factor (GM-CSF) improves the survival of skin flaps in rats. Random skin flaps were raised in 30 male Sprague-Dawley rats, and recombinant GM-CSF 50 μg in 0.5 ml saline solution (n = 15) or 0.5 ml saline solution alone (n = 15) was injected intradermally into the area of the flap after it had been raised. Surviving areas were measured after seven days, and the median area surviving in the group treated with GM-CSF was greater than that in the control group (728 mm2 (range 565-1120) compared with 985 mm 2 (range 636-1368), p = 0.005). These results suggest that in this model, GM-CSF given postoperatively improves the viability of ischaemic skin flaps. © 2005 Taylor & Francis.