Antibiotic-associated Adverse Drug Events in Hospitalized Children Hastanede Yatırılan Çocuklarda Antibiyotikle İlişkili Advers İlaç Olayları
Cocuk Enfeksiyon Dergisi, cilt.16, sa.3, 2022 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 3
- Basım Tarihi: 2022
- Doi Numarası: 10.5578/ced.20229714
- Dergi Adı: Cocuk Enfeksiyon Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Anahtar Kelimeler: Antibiotics, adverse effects, diarrhea, anaphylaxis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Antibiotic use is high in patients hospitalized in the pediatric clinic. Side effects are common in association with antibiotic use. The aim of this study was to reveal antibiotic-associated adverse drug events (antibiotic-associated ADEs) in patients receiving inpatient treatment in the general pediatric clinic. Material and Methods: File records of the patients hospitalized in the pediatric clinic of our hospital between June 2018 and October 2019 were retrospectively analyzed. Antibiotic-associated adverse drug events were recorded. Results: One thousand three hundred and fifty cases were hospitalized in this period. Of these patients, 617 (45.7%) received antibiotics for at least 24 hours and were included in the analysis. A total of 152 cases, 51.3% (n= 78) girls and 48.7% (n= 74) boys, were included in the study. The ages of the cases ranged from 1 to 216 months, with a mean of 24.29 ± 38.6 months. Fifty-four percent of the cases with ADEs were followed up in the service with the diagnosis of acute lower respiratory tract infections, 21.7% bacteremia and sepsis, 20.2% urinary tract infections, and 2.7% skin and soft tissue infections. A total of 152 (24.6%) patients experienced ADE associated with at least one antibiotic. The most common antibiotics caus-ing ADEs were 3rd generation cephalosporins (46.7%), ampicillin-sulbac-tam (21.7%) and aminoglycosides (9.9%). The most common side effects were determined as gastrointestinal system (63.9%), hepatobiliary system (16.5%), skin findings (9.2%) and anaphylaxis (6.6%), respectively. Conclusion: Although antibiotics can play a critical role when used properly, it is necessary to start antibiotics according to the appropriate indications, especially due to our findings that can have severe consequences such as anaphylaxis. In addition, one should be alert in terms of side effects.