The affect of tumour suppressor genes at cancer Kanserde tümör supresör genlerin etkisi
SENDROM, cilt.15, sa.2, ss.71-77, 2003 (Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 15 Sayı: 2
- Basım Tarihi: 2003
- Dergi Adı: SENDROM
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.71-77
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Cancer has both genetic and enviromental causes. In certain cancers, such as gastric and breast cancer, genetic factors play an important, but not exclusive, role in the aetiology. Genetic and environmental factors in the aetiology of of cancer can be differentiated by epidemiologic, family and twin studies and by analysis of disease, biochemical and viral associations. Studies of tumour viruses have revealed genes present in humans known as oncogenes which are involved in carcinogenesis by altering cellular control mechanisms. While the study of oncogenes has revealed much about the cellular biology of the somatic genetic events in the malignant process, the study of hereditary cancer has revealed the existence of what are known as tumour suppressor genes. The recurrence of the malignant phenotype with loss certain chromosomes from the hibrid cells suggested that normal cells contain a gene(s) with tumour suppressor activity which, if lost or inactivite, can lead to malignancy.