A Prospective Study on Postmethylphenidate Treatment Changes in Premature Ejaculation Among Adults With Attention-Deficit/Hyperactivity Disorder
American Journal of Therapeutics, cilt.32, sa.2, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.1097/mjt.0000000000001850
- Dergi Adı: American Journal of Therapeutics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
- Anahtar Kelimeler: ADHD, impulsivity, premature ejaculation, methylphenidate, adult ADHD treatment
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Methylphenidate is widely used to treat attention-deficit/hyperactivity disorder (ADHD), but its impact on comorbid conditions such as premature ejaculation (PE) and impulsivity in adult patients with ADHD is underexplored. Study Question: How does methylphenidate treatment affect impulsivity and PE symptoms in adults with ADHD? Study Design: A prospective cohort study at Erzurum City Hospital included 53 adult patients with ADHD diagnosed through the Structured Clinical Interview for DSM-5 Disorders. Of these, 34 had comorbid PE and 19 did not. Measures and Outcomes: Primary outcomes were changes in ADHD symptoms, impulsivity, and PE, measured by the Adult ADHD Self-Report Scale (ASRS), Urgency, Premeditation, Perseverance, and Sensation Seeking Impulsive Behavior Scale, and the Arabic Index of Premature Ejaculation (AIPE). Secondary outcomes included the correlation between methylphenidate dosage and symptom improvement and predictors of changes in PE symptoms. Results: A significant reduction was observed in the ASRS total score, which decreased from 51.7 ± 9.0 (mean ± SD) to 32.5 ± 8.4 (P < 0.001). Urgency, Premeditation, Perseverance, and Sensation Seeking Impulsive Behavior Scale scores also showed a significant decrease from 125.1 ± 14.3 to 97.0 ± 5.0 (P < 0.001). The AIPE scores, measured in points, increased from 22.4 ± 9.3 to 32.5 ± 8.4 (P < 0.001), suggesting improved control over ejaculation. Correlation analysis revealed a significant positive correlation between the immediate-release methylphenidate dose and improvements in ASRS total scores (r = 0.485, P < 0.001). Regression analysis indicated that the pretreatment AIPE score (b = -0.529, P < 0.001) was a significant predictor of posttreatment changes. Conclusions: Treatment with methylphenidate was associated with a decrease in both impulsivity and PE symptoms in adults with ADHD, particularly with immediate-release formulations. These findings highlight the importance of considering comorbid conditions in ADHD treatment.