Nephrectomy timing for polycystic kidneys in Autosomal dominant polycystic kidney disease patients listed for transplantation
Kidney Transplantation: Efficacy, Safety and Outcomes, NOVA Publications , ss.83-98, 2021
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2021
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.83-98
- Anahtar Kelimeler: Kidney, Nephrectomy, Polycystic, Transplantion
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Autosomal dominant polycystic kidney disease (ADPCKD) is a common hereditary disorder causing end-stage renal disease in approximately 10% of the population worldwide. Its symptoms occur in the third and fourth decades of life, due to kidney enlargement and deformation, subsequently leading to renal failure. The definitive treatment of ADPCKD does not exist and current treatment regimens focus on managing the symptoms. For end-stage renal disease, the best treatment, providing a higher quality of life and overall survival is kidney transplantation. Kidney transplant outcomes are even better with live kidney donations. With live kidney donors, the timing of transplant can be planned and variables can be adjusted to achieve optimal conditions. One of these variables is caused by enlarged and deformed kidneys. These enlarged kidneys may trouble the transplant process by intra-cystic bleeding, infections, stone formations, and mechanical compression of other organs. Additionally, when enlarged below the iliac crest, these kidneys may occupy the space needed for the transplanted kidney. Thus, management of the polycystic kidneys at the pre-transplant period is curial. The decision to remove them, whether to remove single or both kidneys, and the timing of this surgery may affect the outcome of the kidney transplantation significantly.