The assessment of peripapillary retinal nerve fiber layer and macular ganglion cell layer changes in obese children: a cross-sectional study using optical coherence tomography
International Ophthalmology, cilt.37, sa.4, ss.1031-1038, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.1007/s10792-016-0371-8
- Dergi Adı: International Ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1031-1038
- Anahtar Kelimeler: Obese children, Optical coherence tomography, Retinal nerve fiber layer
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To investigate the relationship between the obesity and optical coherence tomography (OCT) parameters. Methods: We studied 54 obese and 33 non-obese children and adolescents. Obesity was defined as BMI higher than 95th percentile (BMI SDS > 1.64). OCT measurements were performed in all participants. Anthropometric and biochemical variables were compared with OCT parameters of 174 eyes. Results: In obese children, in all quadrants retinal nerve fiber layer (RNFL) thicknesses were significantly lower than non-obese children, and also ganglion cell–inner plexiform layer thicknesses in inferior and superiortemporal quadrants were significantly lower in the obese group. BMI SDS, insulin, HOMA-IR and triglyceride levels were negatively correlated with RNFL thickness, significantly (r = −0.386, p < 0.001; r = −0.229, p = 0.002; r = −0.188, p = 0.013; and r = −0.301, p = 0.000; respectively) in all subjects. Conclusions: Thinning in RNFL was detected in normal-looking discs of obese children, and this thinning negatively correlated with BMI SDS. Further studies including large series are needed to clarify whether obesity has an effect on RNFL thickness.