Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-Accelerated mouse prone 8
Age, cilt.35, sa.4, ss.1205-1217, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 4
- Basım Tarihi: 2013
- Doi Numarası: 10.1007/s11357-012-9448-0
- Dergi Adı: Age
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1205-1217
- Anahtar Kelimeler: SAMP8, Accelerated ageing, Stress response, Proteasomal activity, Ascorbic acid, Tocopherol
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n010 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit ?-5. Furthermore, heme oxygenase-1 and paraoxonase-1 (PON-1) status was lower in SAMP8 mice indicating impaired stress response. Biomarkers of inflammation such as C-reactive protein and serum amyloid P were elevated in SAMP8 mice. Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and ?-Tocopherol in the liver. An agedependent increase in hepatic vitamin E and a decline in PON-1 gene expression were also observed in aged compared to young C57BL/6 mice © American Aging Association 2012.