What are the predictors of delirium for patients with lung cancer?
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.78, sa.1, ss.31-38, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 1
- Basım Tarihi: 2021
- Doi Numarası: 10.5505/turkhijyen.2020.60476
- Dergi Adı: Turk Hijyen ve Deneysel Biyoloji Dergisi
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, CAB Abstracts, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.31-38
- Anahtar Kelimeler: delirium, Lung cancer, lymphocyte, neutrophil, platelet
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Delirium is a common psychiatric disorder in advanced cancer but there are a few reports about delirium in patients with lung cancer. We aimed to investigate the predictors of delirium occurring in patients with lung cancer regardless of surgery. Methods: A total of 212 patients over the age of 18 hospitalized with lung cancer for any reason between 2013-2019 were retrospectively investigated in this research. Patients diagnosed with delirium between these dates were determined and patients with concurrent lung cancer diagnosis were selected for this study. A similar number of patients over the age of 18 diagnosed with lung cancer but not diagnosed with delirium in the same period were also defined as the control group. Patients were diagnosed with delirium by the criterias of the Diagnostic and Statistical Manual of Mental Disorders V. criterias during their hospitalization by psychiatrist consultant physician. Age, gender, comorbidities, durations of hospital stay, laboratory parameters at the time of diagnosis (biochemistry, hemogram), the type of lung cancer and existing organ metastases of the patients were recorded from the patient files and hospital information system. Neutrophil to lymphocyte ratio and paletelet to lymphocyte ratio were calculated and recorded. The patients with lung cancer were divided into two groups as patients diagnosed with delirium and without delirium and they were compared. Results: Of the 212 patients, 93.9% of the were male and the average age of the patients was 63.45 ± 8.68 (38- 91) years in our study. The number of the patients with delirium was 126 and the median diagnostic age of the patients with delirium was determined to be 64.00 (59.00- 71.00) years. Although the median levels of white blood cell (WBC), neutrophil, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were higher, the median level of lymphocyte was found to be lower in the group with delirium (p <0.05 ). According to the logistic regression analysis, it was determined that the absence of accompanying chronic obstructive lung diseases (COPD), metastasis, pneumonia and heart disease as well as being a male, increased the delirium risk. Conclusion: NLR and PLR which are systematic inflammatory markers, are associated with delirium and lung cancer. Increased NLR and PLR are significant risk factors for delirium in hospitalized patients with lung cancer and maintaining a low level of an inflammation may help prevent delirium. Male gender and acute illnesses requiring hospitalization may also increase the risk of delirium.