The relationship between Salusin-α, Salusin-β, and Klotho levels with subclinical atherosclerosis in ankylosing spondylitis

Tocoglu, A.G.; DOĞAN, Burcu; Tuzun, S.; Akcay, E.U.; Altas, A.E.; Ayhan, L.T.; YILMAZ, Sabiye; Genc, A.C.; Gonullu, E.; Tamer, A.

doi:10.26355/eurrev_202310_34160

The relationship between Salusin-α, Salusin-β, and Klotho levels with subclinical atherosclerosis in ankylosing spondylitis

Tocoglu A., DOĞAN B., Tuzun S., Akcay E., Altas A., Ayhan L., ...Daha Fazla

European Review for Medical and Pharmacological Sciences, cilt.27, sa.20, ss.9838-9845, 2023 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 27 Sayı: 20
Basım Tarihi: 2023
Doi Numarası: 10.26355/eurrev_202310_34160
Dergi Adı: European Review for Medical and Pharmacological Sciences
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
Sayfa Sayıları: ss.9838-9845
Anahtar Kelimeler: Ankylosing spondylitis, Atherosclerosis, Carotid intima-media thickness, Klotho, Salusin-alpha
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Subclinical atherosclerosis (SA) is often observed in ankylosing spondylitis (AS) patients; Salusin-α (Sal-α), Salusin-β (Sal-β), and Klotho hormones are thought to be associated with atherosclerosis. This study aims to evaluate the relationship between Sal-α, Sal-β, and Klotho levels with SA in AS. PATIENTS AND METHODS: The study included patients older than 18 years who applied between August 1, 2019, and September 1, 2019. Patients with AS were included in the AS group, and patients without a known disease were included in the healthy group. Epicardial adipose tissue thickness (EATT) and carotid intima-media thickness (CIMT) measurements were used to assess SA. RESULTS: The study group included 38 (40.9%) patients diagnosed with AS, and the control group included 55 (59.1%) participants. CIMT and EATT levels were higher in the AS group than in the healthy group [0.37 (0.17) vs. 0.54±0.18, p<0.001; 0.44±0.11 vs. 0.54 (0.18), p=0.004, respectively]. There was no significant difference in Sal-α, Sal-β, and Klotho levels between the AS and healthy groups (p>0.05). Furthermore, there was no observed relationship between EATT or CIMT and Klotho, Sal-α, or Sal-β in either group (p>0.05). CONCLUSIONS: Although SA level was higher in AS patients, there was no relationship between SA and Sal-α, Sal-β, and Klotho levels.