Anti-HAV seropositivity in adult patients with hbsag positive from various locations of Turkey Deǧişik bölgelerden gelen erişkin HBsAg pozitif hastalarda Anti-HAV seropozitifliǧi
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.69, sa.2, ss.61-66, 2012 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.5505/turkhijyen.2012.05924
- Dergi Adı: Turk Hijyen ve Deneysel Biyoloji Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.61-66
- Anahtar Kelimeler: HBV carrier, Hepatitis A, Seropositivity
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Objective: This study aims to determine the rate of hepatitis A virus (HAV) seropositivity in adult HBsAg (+) patients from various regions of Turkey. Method: 137 adult (≥20 age) male patients admitted to Erzurum Mareşal Çakmak Military Hospital in 2009 who were previously diagnosed as HBsAg(+) were included. The subjects were not vaccinated for HAV. Serum samples were analyzed by EIA (enzyme immunassay) using Abbott/AxSYM. Chi-square test was used for statistical analysis of serological data. Results: The Anti-HAV IgG (+) rates was 83.2% in the study populations (114/137), 61.5% (8/13) for those from Marmara region, 83.3% (13/16) for Mediterranean region, 84.6% (22/26) for Mid-Anatolian region, 66.7% (8/12) for Blacksea region, 87.5% (21/24) for East Anatolian region, 94.1% (32/34) for Southeast-Anatolian region. According to our study, no significant difference was found between seven geographical regions due to HAV seropozitivity rates (χ2= 9.511, p=0.147). The seven geographical regions were classified two main grups as East-Southeast Anatolia and other regions. The percentage of anti-HAV positivity rate was significantly higher in East-Southeast Anatolia grup (91.4%; 53/58) compared to other regions grup (77.2%; 61/79) (χ2= 4.803; p=0.028). Conclusion: The prevalance of Hepatitis A varies in different countries and even in different regions of a specific country. Age, low socioeconomic level and worse living conditions have been reported as the most important risk factors in studies with healthy individuals. In this study where subjects with HBsAg(+) were evaluated for anti-HAV positivity, an increase in the risk was found as OR =3.13 times larger (95% confidence interval, 1.09-9.01) when especially living conditions in East-Southeast Anatolia was compared with other regions. It has been postulated that all patients monitored for chronic HBV infection should be assessed for anti-HAV IgG and negative individuals need to be vaccinated due to higher mortality and more severe complications in HBsAg(+) patients.