The Value of SCUBE-1 on Ischemia-Reperfusion Model in Diabetic Patients during Knee Replacement Surgery Diz Protezi Cerrahisi Sırasında Diyabetik Hastalarda İskemi-Reperfüzyon Modelindeki SCUBE-1’in Değeri
Anestezi Dergisi, cilt.28, sa.3, ss.150-157, 2020 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.5222/jarss.2020.80664
- Dergi Adı: Anestezi Dergisi
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.150-157
- Anahtar Kelimeler: Diabetes mellitus, Ischemia-reperfusion model, Malondialdehyde, Signal peptide-CUB-EGF domain-containing protein 1, Total antioxidant status
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Diabetes Mellitus (DM) is a common disease with high mortality and morbidity worldwide. We aimed to assess the oxidative stress levels in patients with and without DM who underwent knee replacement surgery using a pneumatic tourniquet and investigate whether signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) levels are correlated with other ischemia-reperfusion (IR) markers such as malondialdehyde (MDA), and total antioxidant status (TAS). Method: Patients were assigned into either the diabetic (Group D; n=15) or non-diabetic groups (Group C; n=15). MDA, TAS, and SCUBE-1 were assessed at three time points before spinal anesthesia (T1), 5 minutes before (T2) and 2 hours after deflation of the tourniquet (T3). Results: Demographic variables of the groups were similar. There were no statistically significant differences in SCUBE-1, MDA and TAS levels of both groups at all time points. SCUBE-1 levels were higher at T2 and returned to almost normal levels at T3. Conclusion: SCUBE-1, MDA and TAS levels increased following tourniquet application and decreased during the reperfusion period. The magnitude of increase, however, didn’t differ between patients with or without DM. Our results suggest that SCUBE-1 may be used as a marker of tourniquet-related ischemia-reperfusion model.