Evaluation of the relationship of lymphangiogenesis markers with disease pathogenesis in patients with Behçet’s uveitis
Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine, cilt.77, sa.2, ss.387-395, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 77 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.1080/17843286.2021.1890451
- Dergi Adı: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
- Sayfa Sayıları: ss.387-395
- Anahtar Kelimeler: Behç, et’, s Disease, uveitis, lymphangiogenesis, inflammation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: The present study aims to evaluate the relationship between Behçet’s uveitis and lymphangiogenesis by determining levels of Vascular endothelial growth factor-C (VEGF-C, its receptors sVEGFR-2, sVEGFR-3 and lymphangiogenesis markers podoplanin (PDPN) and lymphatic vessel endothelial hyaluronan receptor 1(LYVE-1), and C-type lectin domain family 1 member B (CLEC2). Materials and methods: 55 patients with BD uveitis and 31 healthy control subjects were enrolled in the study. Results: sVEGFR-2, sVEGFR-3, VEGF-C/sVEGFR-2 ratio, PDPN and LYVE-1 levels were higher in the patient group. A positive correlation was found between LYVE-1 and hsCRP levels. PDPN had a strong predictive value for progression with a cut-off value of 2 pg/mL, with 69% sensitivity and 68% specificity (p = 0.001). Conclusion: LYVE-1 and PDPN can be good representatives of the ongoing inflammatory processes in BD uveitis and point out that the disease can be related to lymphangiogenesis.