Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study

Uysal, Mukremin; Saglam, Sezer; Beypınar, İsmail; Saglam, Esra; Mammadov, Elkhan; OCAK, Birol; Aybi, Ozge; Arıkan, Rukiye; ERGEN, ŞEFİKA; Gursoy, Pınar; Sakin, Abdullah; Kaya, Vildan; Ozden, Ercan; EREN, Tülay; Demiray, Atike; Oyman, Abdilkerim; Tatli, Ali; TÜRK, HACI; Gulmez, Ahmet; Demir, Atakan; ALAN, ÖZKAN; Sakalar, Teoman; Sen, Erdem; Ucar, Gokhan; Kilickap, Saadettin; Bilici, Ahmet; ÇOLPAN ÖKSÜZ, DİDEM; Karabulut, Bulent

doi:10.1080/07357907.2025.2595536

Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study

Uysal M., Saglam S., Beypınar İ., Saglam E. K., Mammadov E., OCAK B., ...Daha Fazla

Cancer Investigation, cilt.44, sa.2, ss.127-135, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 44 Sayı: 2
Basım Tarihi: 2026
Doi Numarası: 10.1080/07357907.2025.2595536
Dergi Adı: Cancer Investigation
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO)
Sayfa Sayıları: ss.127-135
Anahtar Kelimeler: Disease-free survival, Local recurrence, Local advanced rectal cancer, Neoadjuvant chemoradiation, Pathological complete response, Overall survival, Surgical outcome
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

The goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT). The clinicopathological characteristics and treatment details of 277 LARC patients with pCR, relapse-free survival (RFS), overall survival (OS), and locoregional and systemic recurrence rates, were assessed. The 5-year RFS and OS rates were 85.6% and 90.9%. The rates of local and systemic recurrence were 3.6% and 7.9%. Our study confirmed the favorable results in survival in patients with LARC who achieved pCR.