The Crucial Role of Body Mass Index on Growth Hormone Stimulation Tests in Children: An Exploration of Potential Gender-Related Differences
Clinical Pediatrics, cilt.64, sa.10, ss.1380-1387, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 64 Sayı: 10
- Basım Tarihi: 2025
- Doi Numarası: 10.1177/00099228251335861
- Dergi Adı: Clinical Pediatrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, Public Affairs Index
- Sayfa Sayıları: ss.1380-1387
- Anahtar Kelimeler: growth hormone stimulation test, gender, obesity, body mass index, clonidine, L-dopa
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The aim of the study was to investigate whether there are any gender-related differences in growth hormone stimulation test (GHST) in prepubertal short children, with a particular emphasis on body mass index (BMI). Prepubertal patients who had two unprimed GHST using clonidine and L-dopa were included in this retrospective study. The anthropometrics and laboratory parameters were evaluated. Patients were categorized based on their peak growth hormone (GH) levels (GH <7 versus ≥7 ng/mL), stimulant agent, and gender. A total of 125 children (Male:Female = 75:50) were included. The mean age of the patients was 7.1 ± 3.0 years. lg-peak clonidine stimulated GH was associated with BMI standard deviation score (SDS) (β [95% CI] = 1.903 [1.665-2.140], P = .003) in females, and with IGF-SDS in males (β [95% CI] = 1.124 [0.910-1.339], P = .026). lg-peak L-dopa stimulated GH was associated with BMI SDS and IGF1-SDS (β [95% CI] = 1.327 [0.968-1.686], P = .009) in females. The blunted effect of BMI showed gender-related differences in the prepubertal pediatric patients.