Invasive breast carcinoma with abundant collagenous stroma shows lower level of CD68-positive tumor associated macrophages than those of invasive carcinoma without abundant collagenous stroma
Acta Biomedica, cilt.92, sa.5, 2021 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 92 Sayı: 5
- Basım Tarihi: 2021
- Doi Numarası: 10.23750/abm.v92i5.10954
- Dergi Adı: Acta Biomedica
- Derginin Tarandığı İndeksler: Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: Breast cancer, CD68, Pseudoangiomatous stromal hyperplasia, Tumor microenvironment, Tumor-associ-ated macrophages
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background and aim of the work: The significance of association between cancer and its stromal microenviron-ment has been recognized. We aimed to investigate the immunohistochemical staining features of D2-40 (podoplanin), SMA (smooth muscle actin) and CD68 (pan-macrophage marker) in patients with early stage invasive breast cancer with/out peritumoral PASH-like stroma. Methods: The H&E sections of core needle bi-opsy specimens of invasive breast carcinomas diagnosed during one-year time period were reviewed in terms of the presence of accompanying PASH-like stroma retrospectively. Cases with similar pattern of growth in their surgical excision materials were included. Eight cases were grouped as ‘Invasive tumor with PASH-like stroma’ and 21 cases as ‘Invasive tumor without PASH-like stroma’, consecutively. The results of immunohis-tochemical staining for D2-40, SMA and CD68 were noted semiquantitatively as ‘negative’,’weak’, moder-ate’ or ‘strong’. Results: CD68 was found significantly lower in invasive tumor with peritumoral PASH-like stroma than those of tumor without PASH-like stroma. No significant differences were found for SMA and D2-40 between two groups. Conclusions: Tumor-associated macrophages (CD68 positive) in tumor stroma have been demonstrated in association with tumor behavior in several studies. The presence of peritumoral PASH-like stroma, which is poorly staining for CD68, might be a morphological clue for the behavior of tumor. (www.actabiomedica.it).