Breastfeeding and secretory factors in idiopathic granulomatous mastitis: Unveiling etiological insights
World Journal of Surgery, cilt.49, sa.1, ss.15-23, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.1002/wjs.12426
- Dergi Adı: World Journal of Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE, Public Affairs Index
- Sayfa Sayıları: ss.15-23
- Anahtar Kelimeler: breastfeeding, etiology, idiopathic granulomatous mastitis, secretion
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Background: Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory, and benign breast disease. Its unclear etiology may involve autoimmune reactions, secretion-related factors, and microorganisms. Aim: To analyze data from our IGM patient series and compare potential etiological factors. Methods: We prospectively collected data using follow-up forms for patients diagnosed with IGM at our breast clinic from September 2014 to December 2020 and analyzed it retrospectively. Results: The study cohort included 220 patients, with a median age of 34 years (range: 20–58). A majority, 217 patients (98.6%), reported a history of breastfeeding, with a median duration of 36 months (range: 0–156). The median interval between the last breastfeeding session and disease onset was 25 (25th–75th percentiles: 15–44) months. Additionally, 116 patients (53.5%) reported breastfeeding-related problems. In 41 surgical patients, dense milky-brown debris in the breast ducts was noted. Although no independent seasonal fluctuations in disease onset were detected, a reduction in IGM cases during the summer months was found to correlate with a general decrease in all breast clinic visits. Conclusion: Most patients reported recent breastfeeding and half experienced related problems, supporting the secretion theory's relevance in IGM's etiology. The absence of seasonal fluctuations suggests that secretion-related factors may be more central to IGM development than autoimmunity or infections. These findings offer crucial insights for future research into IGM's complex causes.