Low vitamin D levels are associated with impaired diastolic function in patients with acute coronary syndrome
Minerva Cardiology and Angiology, cilt.73, sa.1, ss.57-64, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.23736/s2724-5683.24.06515-3
- Dergi Adı: Minerva Cardiology and Angiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.57-64
- Anahtar Kelimeler: Acute coronary syndrome, Vitamin D, Left ventricular dysfunction
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND: Vitamin D deficiency is a common clinical picture associated with poor cardiovascular prognosis. It is also associated with impaired diastolic dysfunction in stable coronary artery disease. We investigated the relationship between vitamin D levels and diastolic dysfunction in patients with acute coronary syndrome (ACS). METHODS: One hundred seventeen patients with the ACS were enrolled in this cross-sectional study. The diastolic function of the patients was evaluated using echocardiography before discharge. We analyzed the relation between serum levels of 25(OH)D and echocardiographic measures of diastolic dysfunction. RESULTS: IVRT and E/e' were found to be significantly greater in patients with low vitamin D levels (115.48±13.64 vs. 106.88±14.80 ms, P<0.05; 10.19±2.80 vs. 8.1±3.2, P<0.05). When regression tests were performed, it was shown that vitamin D level was a predictor (OR=0.935, 95% CI: 0.886-0.987; P=0.015) and independent risk factor (OR=0.942, 95% CI: 0.888-0.998; P=0.042) for the development of diastolic dysfunction. CONCLUSIONS: We found that low vitamin D levels are associated with impaired diastolic function in patients with ACS with preserved left ventricular systolic function.