Investigation of Serum Krebs von den Lungen-6 Level in Patients with Bone Sarcoma and Lung Metastasis
Turkish Archives of Pediatrics, cilt.61, sa.5, ss.438-443, 2026 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 61 Sayı: 5
- Basım Tarihi: 2026
- Doi Numarası: 10.65717/turkarchpediatr.2026.25309
- Dergi Adı: Turkish Archives of Pediatrics
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.438-443
- Anahtar Kelimeler: Bone sarcoma, Ewing sarcoma, Krebs von den Lungen-6, lung, metastasis, osteosarcoma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Serum Krebs von den Lungen-6 (KL-6) level increases in interstitial lung disease and lung cancer. The present study investigated whether there was an increase in serum KL-6 levels in patients with bone sarcoma who were considered positive for lung metastasis. Materials and Methods: Serum samples were collected from patients diagnosed with Ewing sarcoma and osteosarcoma before starting chemotherapy. The samples were frozen and stored at −80°C, and serum KL-6 level was measured using enzyme-linked immunosorbent assay. Results: Serum samples of 47 patients and 42 healthy volunteers were evaluated. At the time of diagnosis, 10 patients had pulmonary tumor metastasis. Patients were followed up for a median of 43 months (1-125 months). At the time of diagnosis, the median KL-6 level of patients with lung metastases was 38.15 U/mL (10.6-155.6 U/mL), while the KL-6 level of patients without lung metastases was 15.2 U/mL (10.7-188.3 U/mL). The difference between these 2 groups was borderline significant (P = .051). The median KL-6 value of the control group was 14.85 U/mL (10.3-188.6 U/mL). When the patients with lung metastasis at the time of diagnosis were compared with the healthy control group, the KL-6 level of the patients was statistically significantly higher than the control group (P = .017). Conclusion: In this pilot study, it was found that serum KL-6 levels were elevated in patients with lung metastasis at the time of diagnosis compared to healthy controls. Serum KL-6 level may be used as an additional parameter to detect pulmonary metastasis, and further studies are needed to confirm this observation.