Contribution of tubarial salivary gland function detected through 68Ga-prostate-specific membrane antigen PET/computed tomography to total salivary gland function
Nuclear Medicine Communications, cilt.46, sa.6, ss.553-557, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 6
- Basım Tarihi: 2025
- Doi Numarası: 10.1097/mnm.0000000000001970
- Dergi Adı: Nuclear Medicine Communications
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.553-557
- Anahtar Kelimeler: (68)GA-prostate-specific membrane antigen, PET/computed tomography, salivary glands function, tubarial salivary glands
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective This study aimed to determine the contribution of tubarial salivary glands to total salivary gland function using quantitative parameters obtained from 68Ga-prostate-specific membrane antigen (PSMA) PET/computed tomography (PET/CT), including salivary gland volume (SV) and salivary gland function (SF). Method This retrospectively designed study included 102 patients with prostate cancer (PCa) who had undergone 68Ga-PSMA PET/CT for staging purposes between January 2022 and December 2023. Patients with missing data, those with tumors in the head and neck region, those who received radiotherapy to the head and neck region, those who underwent surgery in the head and neck region, those with any salivary gland-related disease, those previously treated with radioactive iodine, and those who received lutetium-177 (177Lu) therapy were excluded from the study. Results All 102 patients included in the study were male and diagnosed with PCa. The mean age of the patients was calculated as 72.53 ± 7.58 years. Patients' tubarial SV% and tubarial SF% values were calculated as 7.76 ± 4.01 and 2.58 ± 1.34, respectively. The percentage volume of tubarial glands was found to be statistically significantly higher than that of sublingual glands (P < 0.001, Wilcoxon signed-rank test). No statistical difference, however, was observed in their contributions to total function (P = 0.506). Conclusion When examining the volume ratios of salivary glands showing PSMA expression, it was found that the tubarial salivary glands had a higher volumetric ratio but a lower contribution to total function. We recommend considering these ratios when administering treatments that affect salivary gland functions.