Sexual dysfunction in patients with opioid use disorder: A comparison between naltrexone implant and buprenorphine/naloxone maintenance treatment
Heroin Addiction and Related Clinical Problems, cilt.24, sa.1, ss.47-52, 2022 (SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 1
- Basım Tarihi: 2022
- Dergi Adı: Heroin Addiction and Related Clinical Problems
- Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, CINAHL, EMBASE
- Sayfa Sayıları: ss.47-52
- Anahtar Kelimeler: Naltrexone implant, Opioid use disorder, Sexual dysfunction
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Buprenorphine/naloxone and naltrexone implant have long been regarded as effective treatments for opioid use disorder. Many patients, however, discontinue maintenance therapy because of its side effects, with sexual dysfunction being one of the most common. The aim of this study was to investigate sexual dysfunction in opioid use disorder with respect to buprenorphine/naloxone and naltrexone implant treatment. Methods: The study population consisted of 50 patients on buprenorphine/naloxone, 50 patients on naltrexone implants, and 50 healthy controls. Sexual function was assessed using the International Index of Erectile Function-15. One-way analysis of the variance test was used to compare sexual function between the buprenorphine/naloxone, naltrexone implant, and healthy control groups. Results: Sexual dysfunction was more prevalent in the buprenorphine/naloxone or naltrexone implant groups than in the healthy controls. The buprenorphine/naloxone group had scores that were, statistically, significantly lower than those for the naltrexone implant group in the erectile function (t=-4.801; p<0.001), sexual desire (t=-2.384; p=0.019), intercourse satisfaction (t=-5.859; p<0.001), and overall satisfaction (t=-3.931; p<0.001) domains. Conclusions: Our study showed that naltrexone implant causes less sexual dysfunction than buprenorphine/naloxone treatment. In conclusion, clinicians may consider these findings when treating patients with opioid use disorder who feel concerned about their sexual functions.