Mucocutaneous Manifestations and Associated Factors in Patients with Crohn’s Disease
Turkish Journal of Gastroenterology, cilt.33, sa.11, ss.945-954, 2022 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 11
- Basım Tarihi: 2022
- Doi Numarası: 10.5152/tjg.2022.21750
- Dergi Adı: Turkish Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.945-954
- Anahtar Kelimeler: Crohn's disease, mucocutaneous involvement, risk factors
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: One-third of all extraintestinal manifestations are mucocutaneous findings in patients with Crohn’s disease and there is a relationship between some risk factors. Our aim is to evaluate factors associated with mucocutaneous manifestations in our cohort of patients with Crohn’s disease with a follow-up duration of up to 25 years. Methods: In the study, 336 patients with Crohn’s disease who were followed up between March 1986 and October 2011 were included. The demographic characteristics, Crohn’s disease-related data, and accompanying mucocutaneous manifestations were recorded. The cumulative probability of mucocutaneous extraintestinal manifestations and possible risk factors were analyzed. Results: Oral and skin involvement were detected in 109 (32%) and 31 (9.2%) patients, respectively. The cumulative probability of developing oral and skin manifestations were 43.2% and 20.3%, respectively. Cox regression analysis showed that female gender (odds ratio: 3.28, 95% CI: 1.51-7.14, P = .003) and corticosteroid use (odds ratio: 7.88, 95% CI: 1.07-57.97, P = .043) are independently associated with the development of skin manifestations, while family history (odds ratio: 3.59, 95% CI: 2.18-5.93, P < .001) and inflammatory-type disease (odds ratio: 1.776, 95% CI: 1.21-2.61, P = .004) were independently associated with the development of oral ulcers. Conclusion: Mucocutaneous extraintestinal manifestations are associated with female gender, corticosteroid use, family history, and disease type in a large cohort of patients with Crohn’s disease. Defining the specific relationships of immune-mediated diseases will help to better understand the pathogenesis of Crohn’s disease and associated mucocutaneous manifestations and to use more effective treatments.