Serum adropin, clusterin, hemokinin-1, and kisspeptin levels in patients with migraine
Turkish Journal of Biochemistry, cilt.50, sa.4, ss.530-536, 2025 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 4
- Basım Tarihi: 2025
- Doi Numarası: 10.1515/tjb-2025-0201
- Dergi Adı: Turkish Journal of Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.530-536
- Anahtar Kelimeler: adropin, clusterin, hemokinin-1, kisspeptin, migraine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: Currently, there are no specific biomarkers available for migraine diagnosis. So, we aimed to measure serum levels of adropin, kisspeptin, hemokinin-1, and clusterin in patients with migraine for diagnostic purposes. Methods: The study included 150 participants who were divided into three groups: 50 migraine patients with aura, 50 migraine patients without aura, and a control group of 50 healthy individuals. Participants were selected from those who visited the neurology department between March 2021 and January 2022 and were diagnosed according to the International Headache Society criteria. The study was conducted according to the Standards for the Reporting of Diagnostic Accuracy Studies. Serum levels of adropin, clusterin, hemokinin-1, and kisspeptin were measured using enzyme-linked immunosorbent assay (ELISA) kits. Results: Serum levels of adropin, clusterin, and kisspeptin did not show significant differences between migraine patients and the control group. However, hemokinin-1 levels in migraine patients with aura were significantly higher than those in the control group (p<0.01). The cut-off value for hemokinin-1 was determined to be 0.55ng/L (69.0% sensitivity and 64.8% specificity). No significant correlations were found between sociodemographic data, clinical data, and the serum levels of kisspeptin, hemokinin-1, clusterin, and adropin among patients with migraine with aura. Additionally, there was a significant difference in hemokinin-1 levels when comparing migraine patients with aura to those without aura (p<0.01). Conclusions: Our study showed that hemokinin-1 levels were higher in migraine patients with aura when compared to the control group. Further investigations are needed to confirm this topic.