Polypharmacy, Physical and Nutritional Status, and Depression in the Elderly: Do Polypharmacy Deserve Some Credits in These Problems?
Experimental Aging Research, cilt.47, sa.1, ss.79-91, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 1
- Basım Tarihi: 2021
- Doi Numarası: 10.1080/0361073x.2020.1846949
- Dergi Adı: Experimental Aging Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Abstracts in Social Gerontology, AgeLine, BIOSIS, CINAHL, EMBASE, Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo
- Sayfa Sayıları: ss.79-91
- Anahtar Kelimeler: Polypharmacy, aged, functional status, physical capacity, nutrition, depression
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: To investigate the association of polypharmacy with physical function, nutritional status, and depression in the elderly. Method: The study included 675 people aged over 65 years from 8 centers in various geographical regions. The polypharmacy status was categorized as non-polypharmacy (0–4 drugs), polypharmacy (≥5 drugs). The subjects’ physical function was assessed based on their “physical activity levels, Holden ambulation scores, gait speeds, and hand grip strengths”; their nutritional status based on the “Mini Nutritional Assessment (MNA)”; and their psychological status based on the “Center for Epidemiologic Studies Depression Scale -CES-D”. Results: The presence of polypharmacy in this population was found to be 30% (n = 203). A statistically significant difference was found between the groups on the level of physical activity, Holden ambulation score, and nutrition status (p < .05). There was a statistically significant difference between the groups also on hand grip strength, MNA score, Charlson score (p < .05). Conclusion: Polypharmacy was observed to have a significant association with physical function, nutrition, and depression in the elderly aged ≥ 65 years.