Can Serum ACE Level Be Used as a Prognostic Indicator in COVID-19?
Clinical Laboratory, cilt.68, sa.2, ss.353-358, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.7754/clin.lab.2021.210523
- Dergi Adı: Clinical Laboratory
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.353-358
- Anahtar Kelimeler: angiotensin converting enzyme, angiotensin converting enzyme-2, ACE, ACE-2, COVID-19, ARDS
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: SARS-COV-2 virus that causes COVID-19 binds to the host cell with angiotensin converting en-zyme-2 causing acute respiratory distress syndrome (ARDS) and severe mortality and morbidity. There are stud-ies in the literature conducted on the importance of serum angiotensin converting enzyme (ACE) and ACE-2 en-zymes in ARDS pathogenesis. Serum ACE levels are higher in children and adolescents than in adults, and CO-VID-19 has a milder progression. All these reasons suggest that there may be a relationship between serum ACE levels and COVID-19 prognosis. Methods: The serum ACE levels were determined at the time of hospitalization due to COVID-19 diagnosis in this single-centered, prospective study. According to discharge status, patients were divided into three groups as "Dis-charge with Healing", "Intensive Care Need" and "Mortality", and the effect of serum ACE levels on disease prognosis was investigated. Results: The present study comprised a total of 103 patients, of whom 42.7% (n = 44) were female, and 57.3% (n = 59) were male. The mean age was 59.48 ± 16.47; 91.3% (n = 94) of them were discharged with healing, 5.8% (n = 6) needed intensive care, and 2.9% (n = 3) resulted in mortality. No differences were detected in terms of serum ACE levels between the groups. Conclusions: No relationships were detected between serum ACE levels at the time of hospitalization and COVID-19 prognosis.