Monocyte to HDL Cholesterol Ratio Predicts Coronary Artery Disease Severity and Future Major Cardiovascular Adverse Events in Acute Coronary Syndrome
Heart Lung and Circulation, cilt.25, sa.11, ss.1077-1086, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 11
- Basım Tarihi: 2016
- Doi Numarası: 10.1016/j.hlc.2016.02.023
- Dergi Adı: Heart Lung and Circulation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1077-1086
- Anahtar Kelimeler: Monocyte to HDL ratio, Acute coronary syndrome, Inflammation, Gensini score, SYNTAX score
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background We aimed to investigate the usefulness of monocyte to HDL cholesterol ratio (MHR) in predicting coronary artery disease severity and future major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). Methods 2661 patient with ACS were enrolled and followed up during median 31.6 months. Results MHR were significantly positively correlated with neutrophil to lymphocyte ratio (r = 0.438), CRP (r = 0.394), Gensini (r = 0.407), and SYNTAX score (r = 0.333). During in-hospital and long-term follow-up, MACE, stent thrombosis, non-fatal MI, and mortality occurred more frequently in the third tertile group. Kaplan-Meier analysis revealed the higher occurrence of MACE in the third tertile group compared with other tertiles. Adjusting for other factors, a MHR value in the third tertile group was determined as an independent predictor of in-hospital and long-term MACE. Conclusions MHR as a novel inflammation-based marker seemed to be an independent predictor of severity of coronary artery disease and future cardiovascular events in patients with ACS. MHR may utilise the identification of patients who are at higher risk for MACE and individualisation of targeted therapy.