Does nitrous oxide effect the number and morphology of alveolar macrophages during isofluran-nitrous oxide anaesthesia? Isofluran-azot protoksit anestezisi bronko alveol lavaji sivisinda alevol makrofaj morfoloji ve sayisini degistiriyor mu?
Turk Anesteziyoloji ve Reanimasyon, cilt.27, sa.1, ss.33-37, 1999 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 1
- Basım Tarihi: 1999
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.33-37
- Anahtar Kelimeler: BAL, Isoflurane, Nitrous oxide, Pulmonary alveolar macrophages
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
General anaesthesia is believed to depress both cellular and humoral immune systems. The goal of this study is to see whether nitrous oxide effects the number and morphology of alveolar macrophages harvested by bronchoalveolar lavage (BAL) during isoflurane anaesthesia. The study was approved by the hospital ethics committee and 24 patients who did not have any cardiac, lung disease or need corticosteroid therapy scheduled for abdominal surgery divided into two equal groups. All the patients were premedicated with atropine 0.5 mg + midazolam 0.07 mg/kg. As for induction, thiopentone 7 mg/kg and 1 mg/kg succinylcholine were used. In Group I, anaesthesia was maintained by 1 MAC isoflurane + % 50 N2O/O2, whereas 1 MAC isoflurane + % 50 O2 / air was used in Group II. Ventilation (10 mL/kg/min.) was provided mechanically to maintain an end expiratory CO2 at 30-35 mmHg. Alveolar cells were harvested by BAL after the intubation before inhalation anaesthesia (I) and before the extubation after the inhalation of the gases were stopped (II). ell counts were estimated by microscopic counting after May Grunwald Giemsa staining. The number of immature cells and alveolar macrophages after isoflurane-nitrous oxide inhalation were significantly higher in Group I compared with Group II. It is resulted that the increase in the number of alveolar macrophages and immature cells might be contributed to disruption and toxic effects of N2O on the pulmonary milieu where the other mechanical factors were to be kept constant.