DEVELOPMENT AND OPTIMIZATION OF INDOMETHACIN NANOSUSPENSIONS USING DESIGN OF EXPERIMENT APPROACHES İNDOMETAZİN İÇEREN NANOSÜSPANSİYONLARIN GELİŞTİRİLMESİ VE FAKTÖRİYEL TASARIM YAKLAŞIMI KULLANILARAK OPTİMİZASYONU
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.47, sa.2, ss.1-12, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.33483/jfpau.1194470
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1-12
- Anahtar Kelimeler: Factorial design, indomethacin, nanosuspension, solvent/antisolvent method
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: In this study, it was aimed to prepare nanosuspensions that contains Indomethacin which is a BCS class II drug. To assess the cumulative impact of the chosen variables on the nanosuspension properties, a 34 factorial design was applied and particle size and distributions were examined. Material and Method: In the study, the solvent/antisolvent method was used in the preparation of the suspensions. 34 factorial design. Design-Expert software was used for the evaluation of the prepared formulations in order to obtain the best formulation. PVA concentration, PVA molecular weight, solvent/antisolvent ratio, and ethanol/PEG 300 ratio were used as independent design parameters, and their effects on particle size and distribution were examined. Result and Discussion: Nanosuspensions were successfully prepared by the solvent/antisolvent method. Particle size and polydispersity index of the nanosuspensions were found to be affected by both molecular weight and percentage of PVA in the antisolvent phase (p < 0.05). 0.2% (w/v) PVA; molecular weight of 31 000 for PVA and the solvent-antisolvent ratio as 3:50 were found to be the optimal parameters for the nanosuspension formulations. The particle size and polydispersity of optimum formulation were found 301.5 ± 31.1 nm and 0.159 ± 0.035, respectively.