Predictive Factors for the Prognosis of Vogt-Koyanagi-Harada Disease
Ocular Immunology and Inflammation, cilt.31, sa.8, ss.1687-1693, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 8
- Basım Tarihi: 2023
- Doi Numarası: 10.1080/09273948.2022.2159841
- Dergi Adı: Ocular Immunology and Inflammation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1687-1693
- Anahtar Kelimeler: Optical coherence tomography, predictive factor, prognosis, uveitis, Vogt-Koyanagi-Harada disease
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To identify the prognostic factors in Vogt–Koyanagi–Harada (VKH) disease. Methods: This study included 23 patients (46 eyes) with acute-phase VKHdivided into two subgroups: Group 1; acute-resolved (10 patients), group 2; chronic-recurrent (13 patients). Results: Mean age were 29.5 ± 10.2 years in group 1, 35.8 ± 12.2 years group 2 (p = .033). Best-corrected visual acuity with logMAR at admission was 0.91 ± 0.65 in group 1, 0.88 ± 0.62 in group 2 (p = .798), and improved to 0.08 ± 0.24, 0.18 ± 0.6, respectively (p = .557). Extraocular findings were detected in 30% in group 1, and 53.8% in group 2 at the time of admission (p = .108). All patients were treated with 1 g/day 3–5 days intravenous steroid, and 10 patients had immunomodulatory treatment. Initiation of immunomodulatory therapy did not affect the prognosis (p = .676). Conclusion: Older patients and/or who developed extraocular findings at the presentation were more prone to show recurrences.