Ultrasonographic and fine needle aspiration biopsy characteristics of patients operated for nodular goitre Nodüler guatr nedeniyle opere edilen olgularin ultrasonografi ve tiroid i̇nce i̇ǧne aspirasyon biyopsi özellikleri
Gazi Medical Journal, cilt.25, sa.1, ss.16-19, 2014 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.12996/gmj.2014.04
- Dergi Adı: Gazi Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.16-19
- Anahtar Kelimeler: Thyroid nodule, fine needle aspiration biopsy cytology, ultrasonography, preoperative evaluation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Fine needle aspiration (FNA) biopsy and ultrasonography are themethods used to evaluate thyroid nodules and to predict malignancytogether with the clinical characteristics of nodules. It is important to knowfalse positive and false negative incidences of FNA especially in the case offollicular neoplasia or indeterminate lesions such as atypia of undeterminedsignificance (AUS) to decide whether surgery is necessary or not. The aim ofthis retrospective study was to evaluate ultrasonographic characteristics ofhistopathologically verified malignant thyroid nodules and histopathologic correlation of cytologically indeterminate lesions with histopathologic diagnosis. Methods: One hundred and fifty-four patients who underwentthyroidectomy between January 2010 and January 2012 are included in thisstudy. Demographic characteristics, cytological and histopathological results, preoperative TSH levels of all patients and ultrasonographic characteristics ofthe nodules were evaluated retrospectively. Results: Histopathology of 104 patients (67.5%) was benign and 50 patients(32.5%) was malignant. TSH levels in the group of benign pathology aresignificantly lower than the group of malignant ones. Sensitivity, specifity, positive predictive value and negative predictive value of FNA werecalculated as 90.7%, 72.2%, 62.7%, 93.8%, respectively. Diagnostic accuracyof FNA was 78.5%. Incidence AUS was calculated as 7% and 25% of theselesions were histopathologically malignant. Hypoechogenicity (OR=2.3, p<0.05), microcalcifications (OR=2.5 p<0.05) and increased peripheral andcentral perfusion (0R=11 p<0.05) were the independent risk factors formalignancy. Conclusion: Cytological and hispathological findings of thyroid nodules in ourstudy correlate with other studies. Hypoechoic nodules that havemicrocalsifications and increased peripheral and central perfusion are morelikely to be malignant. © Copyright 2013 by Gazi University Medical Faculty.