Prognostic significance of tumor extension to the main bronchus in the patients with resected right upper lobe lung cancer
Turkish Journal of Thoracic and Cardiovascular Surgery, cilt.19, sa.1, ss.49-54, 2011 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 1
- Basım Tarihi: 2011
- Dergi Adı: Turkish Journal of Thoracic and Cardiovascular Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.49-54
- Anahtar Kelimeler: Adenocarcinoma/pathology/mortality, carcinoma, squamous cell, pneumonectomy, prognosis, survival analysis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: We evaluated the prognostic role of main bronchial extension of right upper lobe tumors in patients with non-small cell lung cancer (NSCLC). Methods: Between 1998 and 2007, the results of surgery in 302 patients with right upper lobe NSCLC were investigated retrospectively. One-hundred-sixty-nine patients with completely resected pT2 o r p T3 tumor without lymph node metastasis were analyzed. The patients were divided into three groups; patients with NSCLC staged as pT2 (n=82), pT3 with invasion of the main bronchus (pT3-MB; n=41), and pT3 patients without main bronchial involvement (n=46). Results: The five-year survival rate of patients with pT3-MB was 36.7%, whereas it was 55.1% for patients with pT2 and 50.7% for patients with other pT3 tumor (p=0.28). Survival of the patients who had undergone pneumonectomy was poorer than that of others (p<0.01). The hilar or interlobar N1 was found to be predictive for poor prognosis (p<0.001). Conclusion: The survival of patients with resected right upper lobe NSCLC with pT3-MB is poor. Our study confirmed that extralobar N1 i s f requently s een a nd i t worsens the prognosis. This coexistence could be the another reason of poor prognosis in patients with main bronchus invaded T3 tumor.