Heparin-coated vs. Non-coated cardiopulmonary bypass circuits: Comparing immediate results with different target activated clotting time
Brazilian Journal of Cardiovascular Surgery, cilt.35, sa.6, ss.913-917, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 6
- Basım Tarihi: 2020
- Doi Numarası: 10.21470/1678-9741-2019-0387
- Dergi Adı: Brazilian Journal of Cardiovascular Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.913-917
- Anahtar Kelimeler: Cardiac Surgical Procedures, Cardiopulmonary Bypass, Erythrocyte Transfusion, Heparin, Hospital Mortality, Intensive Care Units, Length of Stay, Postoperative Period, Silver
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To compare immediate postoperative results in patients receiving heparin-albumin-coated and non-coated circuits. Methods: A total of 241 patients undergoing on-pump cardiac surgery were divided into two groups: those receiving heparin-coated circuits (Bioline®, Maquet Cardiopulmonary AG., Hirrlingen, Germany) and those receiving non-coated circuits (Maquet Cardiopulmonary AG., Hirrlingen, Germany). Results: Activated clotting times (ACT) during cardiopulmonary bypass (CPB) were significantly shorter in the heparin-albumin-coated group than in the non-coated group (355.64±34.12 vs. 560.38±90.20, respectively, P=0.001). In-hospital mortality and postoperative stroke rates and lengths of intensive care unit stay were similar between the groups; in contrast, in the heparin-albumin-coated group, patients had significantly better outcomes for hospital stay, drainage, and need for erythrocyte transfusion. Conclusion: Heparin-coated circuits and reduced level of systemic heparinization with 300 seconds of target ACT level in cardiac surgery under CPB are safe and result in a very satisfactory clinical course.