Successful management of a colchicine overdose with plasmapheresis: a case report
Toxicology Communications, cilt.7, sa.1, 2023 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 1
- Basım Tarihi: 2023
- Doi Numarası: 10.1080/24734306.2023.2286391
- Dergi Adı: Toxicology Communications
- Derginin Tarandığı İndeksler: Scopus
- Anahtar Kelimeler: Colchicine overdose, deliberate self-harm, plasmapheresis, lymphopenia, case report
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
An overdose of colchicine can be lethal due to its narrow therapeutic index. We aimed to describe the successful management of a large intentional overdose with plasmapheresis therapy. A 32-year-old female presented to the Emergency Department with nausea, vomiting, and dizziness eight hours after intentionally ingesting 0.9 mg/kg colchicine in tablet form. She was treated with plasmapheresis and supportive therapy. The only abnormality in four days of observation was one-day transient lymphopenia (0.82 x 109/L).