Direct antiglobulin test positivity in children with acute lymphoblastic leukemia at diagnosis
Pediatric Hematology and Oncology, cilt.32, sa.7, ss.490-494, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 7
- Basım Tarihi: 2015
- Doi Numarası: 10.3109/08880018.2015.1076915
- Dergi Adı: Pediatric Hematology and Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.490-494
- Anahtar Kelimeler: ALL, children, Coombs test, direct antiglobulin test
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Direct antiglobulin test positivity had been reported in the course of some lymphoproliferative neoplasms. However, there are a few case reports describing direct antiglobulin test (DAT) positivity in children with acute lymphoblastic leukemia (ALL). We herein report 8 patients who had positive DAT among 95 newly diagnosed children with ALL. None of these patients had evidence of hemolysis during the follow-up. An antibody was detected in 2 of 8 patients with positive DAT. These 2 children also had positive indirect antiglobulin test (IAT); an autoantibody that was reactive at 4°C, and an alloantibody (anti E) that was reactive at 37°C was detected. We believe DAT positivity in ALL without significant hemolysis is not a rare disorder, and a need for further prospective studies is apparent.