Stereotactic Reirradiation of recurrent nasopharyngeal carcinoma using robotic stereotactic body radiotherapy system: Preliminary results Tekrarlamış nazofarenks karsinomlarının, robotik stereotaktik radyoterapi sistemi kullanılarak i̇kincil Işınlanması: Ön Sonuçlar
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, cilt.22, sa.1, ss.23-30, 2012 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 22 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.4999/uhod.10142
- Dergi Adı: UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.23-30
- Anahtar Kelimeler: Stereotactic radiotherapy, Recurrent nasopharyngeal carcinomas, Robotic stereotactic body radiotherapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Local recurrence of nasopharyngeal carcinoma (NPC) represents a major cause of mortality and morbidity with or without systemic illness. Fractionated Stereotactic radiotherapy (FSRT) is an option for salvage treatment. This study reviewed the treatment outcomes of recurrent NPC in terms of efficacy and toxicity. Between February 2009 and December 2009, 12 patients (8 men and 4 women), median age at diagnosis was 49, (range 18-69) with biopsy proven (10 of 12 patients) locally recurrent NPC were treated using FSRT with Cyber Knife (Accuray Inc. Sunnyvale, CA). Median prescribed dose was 25 Gy (range 24-30) delivered to median 75% isodose line (range 70%-80%) in 5 to 6 fractions. GTVs were delineated using PET-CT images in 5 patients and MRI in 7 patients (median GTV 29.4 ml, range 4.9-78.7). Median follow-up was 11.5 months (range 6-18). Complete response rate after FSRT was 66.7% (8 patients), partial response rate was 33.3% (4 patients). One-year local failure-free survival (LFFS) and overall survival rates were 85% and 75% respectively (2 patients with complete response after FSRT developed local relapse, 4 patients died; the reason for death was disease progression in other sites in 3 patients and treatment related complication in 1 patient). Treatment related grade 3 or more toxicity was observed in 5 patients (33% early and 9% late, total 42.3%). Our preliminary results provided acceptable outcomes with FSRT as a salvage treatment of NPC with regard to early response rate and toxicity.