D-dimer levels in the prediction of the degree of intestinal necrosis of etrangulated hernias in rats
Digestive Diseases and Sciences, cilt.53, sa.7, ss.1832-1836, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 7
- Basım Tarihi: 2008
- Doi Numarası: 10.1007/s10620-007-0088-7
- Dergi Adı: Digestive Diseases and Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1832-1836
- Anahtar Kelimeler: D-dimer, early diagnosis, leucocyte, strangulated intestinal hernia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: The aim of this study was to investigate the time-dependent relation between plasma D-dimer levels and the degree of intestinal necrosis and to compare these parameters with leukocyte counts in an experimental etrangulated hernia model in rats. Results: When the duration of intestinal ischemia was prolonged, serum D-dimer levels increased relative to the control group, with the difference being statistically significant at hour 2 (P = 0.027). In contrast, leukocyte counts in the 2- and 4-h strangulation group were higher that those of the control group, but the difference was not statistically significant (P = 0.625 and P = 0.846, respectively). However, in the 6-h strangulation group the levels of leukocytes were significantly higher that those of the control group (P = 0.015). Conclusion: Serum D-dimer measurements may be used as a more valuable diagnostic parameter than leukocyte count in the early diagnosis of intestinal ischemia, including strangulated hernia. © 2007 Springer Science+Business Media, LLC.