The relationship between the serum uric acid level, neutrophil-lymphocyte ratio, and carotid intima media thickness in chronic kidney disease
Acta Medica Mediterranea, cilt.30, sa.6, ss.1239-1244, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 6
- Basım Tarihi: 2014
- Dergi Adı: Acta Medica Mediterranea
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1239-1244
- Anahtar Kelimeler: Carotid intima media thickness, Chronic kidney disease, Neutrophil-lymphocyte ratio, Uric acid
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aims: The aim of the present study was to investigate the relationship between carotid intima media thickness, and the neutrophil- lymphocyte ratio (NLR) and uric acid level in patients with chronic kidney disease (CKD). Methods: The study included 75 patients (mean age 56.0 ± 15.5 years) with stage 2-5 CKD (non-dialysis). NLR was calculated as the ratio of the neutrophil and lymphocyte counts obtained from the same automated blood sample. Serum uric acid levels were measured and carotid intima media thickness (CIMT) was determined using ultrasonography in each patient. Statistical analysis was performed using the Kolmogorov-Smirnov test, Pearson's and Spearman's correlation analyses and multivariate linear regression analyses. Results: Data show that there was a positive significant correlation between CIMT, and NLR and the serum uric acid level. (r = 0,243, p = 0.035; r = 0,265, p = 0,022, respectively). Conclusion: Based on the present findings, we think that assessment of NLR and the uric acid level could improve the evaluation of the inflammatory process leading to coronary artery disease in patients with CKD.