Does donating blood cause oxidative stress? Kan bağışı oksidatif strese yol açar mı?

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Yilmaz S., GÜRLEK GÖKÇEBAY D., Aykut F., EREN F., NEŞELİOĞLU S., EREL Ö.

Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.82, sa.4, ss.597-606, 2025 (Scopus, TRDizin)

Özet

Objective: Blood donation is a life-saving activity. However, it is indispensable to protect the health of blood donors during and after the donation process. This study aimed to evaluate investigate the effect of blood donation on thiol/disulfide homeostasis by the new automated colorimetric method that measures native thiol (NT), total thiol (TT), disulfide and ischemia modified albumin levels. Methods: A total of 30 voluntary blood donors who were eligible to donate blood were enrolled in this study. Peripheral venous blood samples were collected just before and after 30 minutes blood donation. Demographic data (age, sex, weight, height), and the number of blood donations within one year period of donors, were recorded. Individuals were classified into four age groups: Group 1, 18-30; Group 2, 31-40; Group 3, 40 and over. A repeat donor was defined as a donor who has donated blood at least once in the past. Body-Mass Index (BMI) measurement was calculated by use of the formula weight (kg)/height (m2). Donors were classified according to their BMI values as <25 and ≥ Test parameters of the dynamic thiol/disulfide homeostasis (TDH) were measured by the automated spectrophotometric method. Results: Nineteen of the individuals were first-time donor and the others were repeat donors. There were no significant differences in TDH parameters after blood donation. The IMA levels of repeat blood donors were statistically significantly higher after blood donation while other parameters of THD were not (p=0.04). Statistically significant decreases were found in the levels of native and total thiol in the 18-30 age group donors (p=0.03). Conclusion: Test results of this study showed that blood donation does not cause oxidative stress. Further studies designed with the participation of more blood donors needed to be conducted to present more clearly the association between blood donation and oxidative stress. Considering that blood donation has no adverse effects on human health is considerably valuable in terms of encouraging people to donate blood.