The association of acutetochronic glycemic ratio with noreflow in patients with STsegment elevation myocardial infarction undergoing primary percutaneous coronary intervention
Kardiologia Polska, cilt.79, sa.2, ss.170-178, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Özet
- Cilt numarası: 79 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.33963/kp.15736
- Dergi Adı: Kardiologia Polska
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
- Sayfa Sayıları: ss.170-178
- Anahtar Kelimeler: acute-to-chronic glycemic ratio, myocardial infarction, no-reflow, percutaneous coronary intervention
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background No-reflow (NR) is a strong and independent predictor of poor cardiovascular outcomes among patients with ST-segment elevation myocardial infarction (STEMI). aims The aim of the study was to investigate the association of the acute-to-chronic (A/C) glycemic ratio with no-reflow (NR) in STEMI patients following primary percutaneous coronary intervention (PCI). methods This retrospective study included 905 patients with STEMI. The A/C glycemic ratio was determined as admission blood glucose (ABG) divided by the estimated average glucose (eAG). We evaluated 2 primary models (full model and reduced model). The primary outcome was the presence of NR. results The incidence of NR was 22.7% (206 cases) in the present study. We divided the study population into 3 tertiles (T1, T2, and T3) based on the ABG/eAG ratio. There was a stepwise increase of the frequency of NR from the T1 to T3 group (36 patients [12%] vs 70 patients [23%] vs 100 patients [33%]; respectively [P <0.001, for each group comparison]). In a full model, the ABG/eAG ratio (OR, 2.274; 95% CI, 1.587–3.26; P <0.001) was associated with NR. After the performance of a step-down backward variable selection method, the thrombus grade, the ABG/eAG ratio, the infarct-related artery diameter, and age remained in the reduced model. The ABG/eAG ratio (contributing 25.3% of the explainable outcome in the model) was one of the strong predictors of NR in the reduced model. conclusions To our knowledge, this might be the first study showing a significant relationship between the ABG/eAG ratios with NR in patients with STEMI after primary PCI.