Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome Polikistik over sendromunda insülin rezistansı ve nöropeptid Y düzeyleri arasındaki ilişkinin araştırılması
Marmara Medical Journal, cilt.32, sa.1, ss.1-6, 2019 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.5472/marumj.500032
- Dergi Adı: Marmara Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1-6
- Anahtar Kelimeler: Polycystic ovary syndrome, Insulin resistance, Neuropeptide Y
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The aim of study is to investigate the relationship between neuropeptide Y (NPY) and insulin resistance which is important in the pathogenesis of polycystic ovary syndrome (PCOS). Materials and Methods: This study was conducted between May 2012 and May 2013. The study included 45 patients with PCOS and 44 healthy controls at productive age. Insulin, fasting blood sugar, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, testestorone, dehydroepiandrosterone sulfate (DHEA-S), thyroid stimulating hormone (TSH), cortisol, estradiol, and NPY levels were measured at early follicular phase in patients with PCOS, while, insulin, fasting blood sugar, prolactin, DHEA-S, TSH, cortisol, and 17-OH progesterone levels were measured in control group. Homeostatic model assessment for insulin resistance (HOMA-IR) scores were calculated and antrepometric measures were recorded. Pelvic ultrasonography was performed. Results: Fasting insulin levels and HOMA-IR scores showed insulin resistance to be higher in obese patients with PCOS when compared with healthy controls and patients with normal weight PCOS. NPY levels were found to be higher in obese-overweight patients with PCOS than the values observed in healthy controls and in patients with normal weight but they were not statistically significant (P>0.05). NPY levels did not differ in patients with and without insulin resistance. Conclusion: No correlation was dedected between insulin resistance and NPY levels but NPY levels were higher in overweight PCOS patients.